3D Structure of Partial Steroid Receptor Bound to DNA
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On this page, you can see fragments of two identical molecules that function as steroid receptors and transcription factors. The steroid-binding portion has been trimmed off to focus on the DNA-bind domains. You can click and drag to see the shape before clicking on the buttons below.
Highlight the DNA strands as red and blue. Turn the two subunits purple and yellow.
Redraw the proteins in cartoon form, highlighting the alpha helices in pink spirals. Then zoom in to see how the proteins protrude into the major grooves of the promoter DNA.
Redraw the proteins in wireframe and change their colors. The monomer on the right shows each atom in CPK colors while the monomer on the left is colored yellow to help you distinguish the two subunits. Do the proteins reach out to touch any of the bases of the DNA? In which groove or grooves?
Look on the back side of the DNA too.
© Copyright 2013 Department of Biology, Davidson College, Davidson, NC 28035
Send comments, questions, and suggestions to: macampbell@davidson.edu