GcatWiki - User contributions [en]

How to deal with multi-named genes

2011-02-24T15:59:50Z

Laivey: /* BLAST */

When investigating a gene, one always must be leery of the possibility that the gene of interest may be referred to by multiple names within the research world. Important Information can be overlooked by assuming a gene only has one name within and across species. This tutorial demonstrates ways to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein. She mentions the gene that encodes the OSCP protein also has the gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and with great excitement, you realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered the ''ATP5O/OSCP'' gene in a species that encodes OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not always listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T15:58:57Z

Laivey: /* Summary */

When investigating a gene, one always must be leery of the possibility that the gene of interest may be referred to by multiple names within the research world. Important Information can be overlooked by assuming a gene only has one name within and across species. This tutorial demonstrates ways to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein. She mentions the gene that encodes the OSCP protein also has the gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and with great excitement, you realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not always listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T14:41:08Z

Laivey: /* Finding Your Gene of Interest */

When investigating a gene, one always must be leery of the possibility that the gene of interest may be referred to by multiple names within the research world. Important Information can be overlooked by assuming a gene only has one name within and across species. This tutorial demonstrates ways to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein. She mentions the gene that encodes the OSCP protein also has the gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and with great excitement, you realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T13:35:48Z

Laivey:

When investigating a gene, one always must be leery of the possibility that the gene of interest may be referred to by multiple names within the research world. Important Information can be overlooked by assuming a gene only has one name within and across species. This tutorial demonstrates ways to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein. She mentions the gene that encodes the OSCP protein also have the gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and with great excitement, you realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T02:44:12Z

Laivey: /* Navigating NCBI' */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name within its own and across species. This tutorial demonstrates how to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T02:43:41Z

Laivey:

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name within its own and across species. This tutorial demonstrates how to determine if a gene has been assigned multiple names.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T02:42:36Z

Laivey: /* Summary */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with ''OSCP'' in the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T02:41:55Z

Laivey: /* Summary */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Genes may have one or more names across species, or even within the same species. As in the case with OSCP on the ''Drosophila'' page, all of the alternative names for the gene are not alway listed, therefore additional investigation can be quite fruitful when it comes to research. Utilize as many database as you can, such a NCBI, Pubmed, GeneCards and BLAST to discover if there is variance in the name of your gene of interest. Knowing all the names a gene has been assigned, will help maximize the amount of information you find about the gene of interest.

How to deal with multi-named genes

2011-02-24T02:35:47Z

Laivey:

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

[[File:OSCP.jpg]]

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

File:OSCP.jpg

2011-02-24T02:34:40Z

Laivey:

How to deal with multi-named genes

2011-02-24T02:34:26Z

Laivey: /* Finding Your Gene of Interest */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

[[File:OSCP.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:30:36Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. The name of the protein the nucleotide sequence hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ''ATP5O/OSCP'' genes that encode OSCP protein.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

File:FASTA.jpg

2011-02-24T02:28:38Z

Laivey: uploaded a new version of "File:FASTA.jpg"

How to deal with multi-named genes

2011-02-24T02:28:20Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.
[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ATP5O/OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:25:21Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products". You can either copy and paste the entire sequence into the BLAST box or use the Ref number. The Ref number in this case is NC_000021.8 for ATP50. This time, you choose to copy and paste the nucleotide sequence.

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and paste the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ATP5O/OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:18:51Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organisms, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the human ATP5O page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''ATP5O'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered more ATP5O/OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:14:56Z

Laivey: /* GeneCards */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.

[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:14:27Z

Laivey: /* Is It the Same Gene? */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. This suggest that ATP50 is the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:12:46Z

Laivey: /* GeneCards */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of ''OSCP'' in the "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not include ''ATP50'' or ''ATP0'' in the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:11:10Z

Laivey: /* GeneCards */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
The presence of an "Also Known As" section is a little strange because the ''Drosophila'' ''OSCP'' page did not have the "Also Known As" section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:10:00Z

Laivey: /* Is It the Same Gene? */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You click onto the ATP50 link and you scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:08:44Z

Laivey:

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

==''Navigating NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:07:58Z

Laivey: /* First Step: NCBI */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You then NCBI Gene search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

File:GENE.jpg

2011-02-24T02:06:58Z

Laivey:

How to deal with multi-named genes

2011-02-24T02:06:42Z

Laivey: /* Finding Your Gene of Interest */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."
[[File:GENE.jpg]]

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:04:27Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find ''OSCP'' in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then go to [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] and past the FASTA sequence into the BLAST box. Click BLAST and you compare the nucleotide sequence of ''Drosophila OSCP'' against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:02:17Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find the OSCP in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then you [http://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAST_PROGRAMS=megaBlast&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome/ BLAST] the nucleotide sequence against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T02:00:42Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find the OSCP in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".

[[File:FASTA.jpg]]

Then you BLAST the sequence against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

File:FASTA.jpg

2011-02-24T02:00:20Z

Laivey:

How to deal with multi-named genes

2011-02-24T02:00:01Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find the OSCP in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. From NCBI Gene, you again go to the ''Drosophila melanogaster'' OSCP page and find the FASTA nucleotide sequence located under "Genomic regions, transcripts, and products".
[[File:FASTA.jpg]]

Then you BLAST the sequence against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T01:56:41Z

Laivey: /* BLAST */

One always must be leery of the possibility that a gene may have multiple names. When investigating a gene, information can be overlooked by assuming a gene only has one name across species. This tutorial demonstrates how to determine if a gene is referred to by multiple names across species.

=='''Finding Your Gene of Interest'''==

Say you just are sitting in Biology class and your teacher mentions ATP synthase has a subunit within its complex that is resistant to oligomyocin called Oligomyocin Sensitivity Conferring Protein, gene name ''OSCP''. This sparks your interest, and you want to investigate this gene more. After class you immediately run home, and go to [http://www.ncbi.nlm.nih.gov/gene/ NCBI Gene] and search for "OSCP."

=='''First Step: NCBI'''==

Perfect! You get a hit for ''OSCP'' in ''Drosophila melanogaster''. You review the page and realize you want to research ''OSCP'' in other organisms, including humans. You pubmed search "OSCP homo sapiens." You get hits, but none specifically say OSCP. The first hit is for a gene called ''ATP50''.

[[File:ATP50.jpg]]

==='''Is It the Same Gene?'''===

You scroll down to "General Protein Information," as see that gene does encode for oligomyocin sensitivity conferring protein. It must be the ''OSCP'' in humans, just referred to by another name.
[[File:GPI.jpg]]

You also notice that there "Also Known As" section, that indicates the gene goes by the names: ''ATPO; OSCP; ATP5O''.
[[File:ATP502.jpg]]

==More Databases for More Verification==
==='''GeneCards'''===
This is a little strange because the ''Drosophila'' ''OSCP'' page did not have a also known as section.
You decide to get further confirmation that ''OSCP'' is ''ATP50''. You search "OSCP" on [http://www.genecards.org/ GeneCards], a database for human genes, and get "ATP50" as a hit. That seems promising.
[[File:GeneCards.jpg]]

==='''BLAST'''===

You decide you want to find the OSCP in other organism, but do not want to go through the hassel of searching all of NCBI for alternative names, like you did for Homo sapiens. You obtain the FASTA nucleotide sequence for OSCP in Drosophila from the NCBI Gene.
[[File:FASTA.jpg]]

Then you BLAST the sequence against all organisms in the BLAST database. Yes! You get lots of hits. The name of the protein the hit encodes is clearly shown, making it easy to detect whether or not you have discovered OSCP genes.

=='''Summary'''==

Gene may have one or more names across species. As in the case with OSCP on the Drosophila page, the alternative name for the gene are not alway listed. Utilize as many database such a NCBI, Pubmed, GeneCard and Blast to discover if there is variance in the names.

How to deal with multi-named genes

2011-02-24T01:52:18Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:51:26Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:48:38Z

Laivey:

File:GeneCards.jpg

2011-02-24T01:46:45Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:46:13Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:44:35Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:43:08Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:40:51Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:38:51Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:28:27Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:27:48Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:24:43Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:24:27Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:23:46Z

Laivey:

File:GPI.jpg

2011-02-24T01:22:28Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:22:08Z

Laivey:

File:ATP502.jpg

2011-02-24T01:20:11Z

Laivey:

How to deal with multi-named genes

2011-02-24T01:19:56Z

Laivey:

File:ATP50.jpg

2011-02-24T01:15:53Z

Laivey: uploaded a new version of "File:ATP50.jpg"