Missouri Western/Davidson iGEM2009
This space will be used starting April, 2009 for brainstorming and a shared whiteboard space.
MWSU-Davidson 2009 iGEM team photo
The Davidson College part of the 2009 iGEM Team
We need to learn more about these topics:
- How do signal sequences/peptides work in bacteria, and how can we use them?
- Plasmid Creation
- What is msDNA?
- How is msDNA normally produced? Olivia/Alyndria
- How many copies are carried per cell? Alyndria
- What would we need to do to turn this into a BioBrick device? Romina
- How could we swap out msDNA sequences? Shamita
- What role can physical modeling of protein structure play in our project?
- What role can physical modeling of proteins play in our project? Eric Sawyer
- What other cool reporters are there? (Discrete On/Off or Continuous) Bryce Szczepanik
- Can we use promoter strength/opposite directions to subtract? Clif Davis
- Can we use suppressor tRNAs to encode logical operators (suppressor suppressor logic, SSL)?
- How is msDNA stored in E. coli? Olivia
- What is the sequence of bacterial reverse transcriptase and can we clone that gene? Shamita
- Can we redesign the normal msDNA pathway to produce new segments of DNA of our choosing? All
- What are other available reverse transcriptases? Leland
- What other math problems (e.g. NP- complete) are accessible to us? Annie Siya Sun
- What is the relationship between 3-SAT and map coloring? Ashley Schnoor
- What activators are there that turn on a promoter without any help?
- Can we use protein interactions to compute? (Post-translation, proteases, quaternary structure) Will Vernon
- Could we do something with clocks/counting?
- Could we have/use multiple synthetic organelles in a cell?
- What ideas from previous iGEM teams are useful to us?
- Examples of Metabolic Pathways in E.coli
- Can we get bacteria to solve a problem large enough to challenge a person?
- What interesting challenges or problems does origami offer?
- Can we produce a series of increasingly difficult goals that might be possible to produce in the lab?
- What has been done before and how can we improve upon that?
- We can perform some pilot experiments using synthesized DNA and later switch to msDNA (maybe).
- Can we address the Boolean Satisfiability (SAT) problem with a bacterial computer?
- How has 3SAT been addressed with a DNA computer? Can we use those methods?
- Can we get bacteria to solve a problem large enough to challenge a computer (probably not, but it is fun to think about)?
- What are some linear algebra applications for DNA origami?
- How can we use origami to solve 3-SAT problems?
- What constructs are we testing?
- What school districts do we have access to?
- Where is the Synthetic Biology page we want high school teachers to use after the survey?
- Do you need any more input from the veterans before the survey is ready?
Here is a link to the animation of the Hin/Hix system created by the "E. HOP living computer project folks.