Mouse Down Syndrome ES RNAseq Project

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Lab Methods in Genomics, Spring 2017

We will be looking at the transcriptome of mouse embryonic stem cells (ES) that have an extra copy of the human orthologous chromosome #21 which causes Down Syndrome. In particualr, we will be looking at two different populations of cells. One population will have the father's extra copy of "chromosome #21". The other popuation wil have the mother's extra chromosome. This class has three components that contribute to its research foundation.

  1. We will search for any differences in the transcriptomes of these two different sources of ES.
  2. We will be collaborating with a class from Colby College in Maine; Dr. Andrea Tilden will be offering a parallel course for her students. We will benefit from collaborating with her students as we conduct our research because both classes will exchange information that could be of interest to everyone. This collaboration mirrors modern research in the post-genomics era.
  3. We are also collaborating with Drs. Charlie Wray and Laura Reinholdt at Jackson Laboratory in Bar Harbor, ME. We are part of an educational pilot experiment to see if it is feasible to offer research experiences to a national network of undergraduates using RNAseq data to answer legitmate research questions.


Web Tools

Papers about Embryonic Stem Cells

Papers/Resources about Down Syndrome

Down Syndrome Overview

Davidson Research Teams