History and Background - Revision history

Dajordan: /* Discovery */

2009-10-27T04:03:15Z

‎Discovery

Dajordan: /* Discovery */

2009-10-27T04:02:48Z

‎Discovery

Dajordan at 07:58, 6 December 2007

2007-12-06T07:58:23Z

Dajordan at 07:57, 6 December 2007

2007-12-06T07:57:57Z

Dajordan: /* RNA world hypothesis */

2007-12-06T07:55:44Z

‎RNA world hypothesis

Dajordan: /* Function in Natural Systems */

2007-12-06T07:54:55Z

‎Function in Natural Systems

Dajordan: /* Discovery */

2007-12-06T07:54:03Z

‎Discovery

Dajordan: /* Discovery */

2007-12-06T07:53:43Z

‎Discovery

Dajordan: /* RNA world hypothesis */

2007-12-06T07:50:42Z

‎RNA world hypothesis

Dajordan: /* RNA world hypothesis */

2007-12-06T07:50:24Z

‎RNA world hypothesis

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 [[Applications of Ribozymes in Synthetic Systems - Danielle Jordan]]
 == Discovery ==
-In 1967, Carl Woese, Francis Crick and Leslie Orgel hypothesized that RNA molecules could be used as catalysts based on their complex secondary structures. It was not until 1982 when Thomas R. Cech first showed that RNA molecules could be used as catalysts of chemical reactions, for which won the Nobel prize along with Sidney Altman in 1989.  However, the term "ribozyme" was coined by Kelly Kruger ''et al'' in a paper published in ''Cell'' in 1982. Since then, ribozymes have proven to be an important area of research in gene technology [http://en.wikipedia.org/wiki/Ribozyme (Wikipedia)].
+In 1967, Carl Woese, Francis Crick and Leslie Orgel hypothesized that RNA molecules could be used as catalysts based on their complex secondary structures. It was not until 1982 when Thomas R. Cech first showed that RNA molecules could be used as catalysts of chemical reactions, for which he won the Nobel prize along with Sidney Altman in 1989.  However, the term "ribozyme" was coined by Kelly Kruger ''et al'' in a paper published in ''Cell'' in 1982. Since then, ribozymes have proven to be an important area of research in gene technology [http://en.wikipedia.org/wiki/Ribozyme (Wikipedia)].
 == Function in Natural Systems ==

@@ Line 1: / Line 1: @@
 [[Applications of Ribozymes in Synthetic Systems - Danielle Jordan]]
 == Discovery ==
-In 1967, Carl Woese, Francis Crick and Leslie Orgel hypothesized that RNA molecules could be used as catalysts based on their complex secondary structures. It was not until 1982 when Thomas R. Cech first showed that RNA molecules could be used as catalysts of chemical reactions, for which won the Nobel Peace prize along with Sidney Altman in 1989.  However, the term "ribozyme" was coined by Kelly Kruger ''et al'' in a paper published in ''Cell'' in 1982. Since then, ribozymes have proven to be an important area of research in gene technology [http://en.wikipedia.org/wiki/Ribozyme (Wikipedia)].
+In 1967, Carl Woese, Francis Crick and Leslie Orgel hypothesized that RNA molecules could be used as catalysts based on their complex secondary structures. It was not until 1982 when Thomas R. Cech first showed that RNA molecules could be used as catalysts of chemical reactions, for which won the Nobel prize along with Sidney Altman in 1989.  However, the term "ribozyme" was coined by Kelly Kruger ''et al'' in a paper published in ''Cell'' in 1982. Since then, ribozymes have proven to be an important area of research in gene technology [http://en.wikipedia.org/wiki/Ribozyme (Wikipedia)].
 == Function in Natural Systems ==

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 http://www.biochemj.org/bj/317/0855/bj3170855f01.gif
-[http://www.biochemj.org/bj/317/0855/bj3170855f01.gif Image Link]
+[http://www.biochemj.org/bj/317/0855/bj3170855f01.gif Image Source Link]
 == RNA world hypothesis ==
 Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid [http://en.wikipedia.org/wiki/RNA_world_hypothesis (Wikipedia)].

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 http://www.biochemj.org/bj/317/0855/bj3170855f01.gif
 == RNA world hypothesis ==
 Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid [http://en.wikipedia.org/wiki/RNA_world_hypothesis (Wikipedia)].

← Older revision		Revision as of 07:55, 6 December 2007
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	== RNA world hypothesis ==		== RNA world hypothesis ==
−	Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function ~~[http://en.wikipedia.org/wiki/RNA_world_hypothesis (Wikipedia)]~~. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid.	+	Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid [http://en.wikipedia.org/wiki/RNA_world_hypothesis (Wikipedia)].

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 == Function in Natural Systems ==
-The existence of ribozymes in natural systems is fairly rare, which is not to say that they are not important. In essense, the active part of the ribosome that translates RNA can be considered a ribozyme.  Some examples of known ribozymes are listed below (such as the hammerhead ribozyme, which is of particular interest for its property of self-cleaving catalytic activity).
+The existence of ribozymes in natural systems is fairly rare, which is not to say that they are not important. In essense, the active part of the ribosome that translates RNA can be considered a ribozyme.  Some examples of known ribozymes are listed below (such as the hammerhead ribozyme, which is of particular interest for its property of self-cleaving catalytic activity) [http://en.wikipedia.org/wiki/Ribozyme (Wikipedia)].
 === Types of Natural Ribozymes ===
 *[http://en.wikipedia.org/wiki/Ribosomal_RNA Peptidy transferase 23S rRNA]

← Older revision		Revision as of 07:50, 6 December 2007
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	== RNA world hypothesis ==		== RNA world hypothesis ==
−	Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function [http://en.wikipedia.org/wiki/RNA_world_hypothesis Wikipedia]. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid.	+	Walter Gilbert proposed in 1986 that in the cell's ancient past, RNA was used both for carrying genetic material and for catalyzing chemical reactions, unlike the classical division between DNA and proteins. This theory is known as the "RNA world hypothesis" and became a popular view for the origin of cellular function [http://en.wikipedia.org/wiki/RNA_world_hypothesis (Wikipedia)]. According to this theory, RNA preceded DNA as the method for transmition of cellular information by acting as both an enzyme and a nucleic acid.