Translational Bursting - Revision history

Miwaters at 14:40, 6 December 2007

2007-12-06T14:40:22Z

Miwaters at 14:37, 6 December 2007

2007-12-06T14:37:56Z

Miwaters at 14:34, 6 December 2007

2007-12-06T14:34:11Z

Miwaters at 00:07, 6 December 2007

2007-12-06T00:07:30Z

Miwaters at 19:52, 5 December 2007

2007-12-05T19:52:37Z

Miwaters at 19:51, 5 December 2007

2007-12-05T19:51:54Z

Miwaters at 19:39, 5 December 2007

2007-12-05T19:39:35Z

Miwaters at 19:38, 5 December 2007

2007-12-05T19:38:33Z

Miwaters at 19:33, 5 December 2007

2007-12-05T19:33:47Z

Miwaters at 19:32, 5 December 2007

2007-12-05T19:32:47Z

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 ==Translational Bursting is the Main Source of Stochasticity in Prokaryotes==
-The amount of protein translated per strand of mRNA produced is characterized as a transcript's translational effciency or "burst parameter". Proteins are translated from mRNA in a pulsatile manner often described as "short bursting". Genes that are regulated by operons with low translational efficiency have a lower amount of noise than those exhibiting high translational efficiency. This is becuase a lower amount of mRNA in the cell means that the concentration of mRNA's are more susceptible to stochastic events such as mRNA degredation or binding of transcription factors.
+The amount of protein translated per strand of mRNA produced is characterized as a transcript's translational efficiency or "burst parameter". Proteins are translated from mRNA in a pulsatile manner often described as "short bursting". Genes that are regulated by operons with low translational efficiency have a lower amount of noise than those exhibiting high translational efficiency. This is because a lower amount of mRNA in the cell means that the concentration of mRNA's are more susceptible to stochastic events such as mRNA degradation or binding of transcription factors.
 <br>
 <center>Figure 1 <br>[[Image:Translationalbursting.png | 250 px]]<br> Figure 1 obtained from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400249 permission pending <br> </center>
-Figure 1 visually depicts the varying levels of noise in response to varying levels of mRNA and translational efficieny. Due to the stochastic nature of translation, larger concentrations of mRNA result in less stochasticity as a result of translational machinery.
+Figure 1 visually depicts the varying levels of noise in response to varying levels of mRNA and translational efficiency. Due to the stochastic nature of translation, larger concentrations of mRNA result in less stochasticity as a result of translational machinery.
@@ Line 15: / Line 15: @@
 <br>
-Figure 2 depicts The dependencies of [[ Noise as a Variable | noise and noise strength]] on the average protein abundance when transcription rate (size of system) and translational efficiency are increased in a prokaryotic cell. The green line represents the varying translational effciency and the pink line represents the varying transcriptional rate. When comparing the slopes of the lines in figure B, translational effciency has a much greater effect on noise strength. [[Promoter Kinetics|Find out why in the next section.]]
+Figure 2 depicts The dependencies of [[ Noise as a Variable | noise and noise strength]] on the average protein abundance when transcription rate (size of system) and translational efficiency are increased in a prokaryotic cell. The green line represents the varying translational efficiency and the pink line represents the varying transcriptional rate. When comparing the slopes of the lines in figure B, translational efficiency has a much greater effect on noise strength. [[Promoter Kinetics|Find out why in the next section.]]
 <br><br><br>
 <center>[[Promoter Kinetics |Next Section in Origins and Characterization]] | [[Origins and Characterization of Stochasticity | Back to Origins and Characterization Home]] </center>

@@ Line 15: / Line 15: @@
 <br>
-Figure 2 depicts The dependencies of [[ Noise as a Variable | noise and noise strength]] on the average protein abundance when transcription rate and translational efficiency are increased. Green represents the varying translational effciency and pink represents the varying transcriptional rate. When comparing the slopes of the lines in figure B, translational effciency has a much greater effect on noise strength.
+Figure 2 depicts The dependencies of [[ Noise as a Variable | noise and noise strength]] on the average protein abundance when transcription rate (size of system) and translational efficiency are increased in a prokaryotic cell. The green line represents the varying translational effciency and the pink line represents the varying transcriptional rate. When comparing the slopes of the lines in figure B, translational effciency has a much greater effect on noise strength. [[Promoter Kinetics|Find out why in the next section.]]
 <br><br><br>
 <center>[[Promoter Kinetics |Next Section in Origins and Characterization]] | [[Origins and Characterization of Stochasticity | Back to Origins and Characterization Home]] </center>

@@ Line 1: / Line 1: @@
 ==Translational Bursting is the Main Source of Stochasticity in Prokaryotes==
-The amount of protein translated per strand of mRNA produced is characterized as a transcript's translational effciency or "burst parameter". Proteins are translated from mRNA in a pulsatile manner often described as "short bursting". Genes that are regulated by operons with low translational efficiency have a lower amount of noise than those exhibiting high translational efficiency. This is becuase a lower amount of mRNA in the cell means that the concentration of mRNA's are more susceptible to stochastic events such mRNA degredation.
+The amount of protein translated per strand of mRNA produced is characterized as a transcript's translational effciency or "burst parameter". Proteins are translated from mRNA in a pulsatile manner often described as "short bursting". Genes that are regulated by operons with low translational efficiency have a lower amount of noise than those exhibiting high translational efficiency. This is becuase a lower amount of mRNA in the cell means that the concentration of mRNA's are more susceptible to stochastic events such as mRNA degredation or binding of transcription factors.
 <br>
 <center>Figure 1 <br>[[Image:Translationalbursting.png | 250 px]]<br> Figure 1 obtained from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400249 permission pending <br> </center>

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 The amount of protein translated per strand of mRNA produced is characterized as a transcript's translational effciency or "burst parameter". Proteins are translated from mRNA in a pulsatile manner often described as "short bursting". Genes that are regulated by operons with low translational efficiency have a lower amount of noise than those exhibiting high translational efficiency. This is becuase a lower amount of mRNA in the cell means that the concentration of mRNA's are more susceptible to stochastic events such mRNA degredation.
 <br>
-<center>Figure 1 <br>[[Image:Translationalbursting.png | 250 px]]<br> Image obtained from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400249 permission pending <br> </center>
+<center>Figure 1 <br>[[Image:Translationalbursting.png | 250 px]]<br> Figure 1 obtained from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400249 permission pending <br> </center>
 Figure 1 visually depicts the varying levels of noise in response to varying levels of mRNA and translational efficieny. Due to the stochastic nature of translation, larger concentrations of mRNA result in less stochasticity as a result of translational machinery.

@@ Line 11: / Line 11: @@
 <br>
 <center>Figure 2 <br>[[Image:Noise_strength.png| 300 px]]
-<br></center>
+<br>
-Figure 2 was obtained from http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15883588&cmd=showdetailview&indexed=google permission pending
+Figure 2 was obtained from http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15883588&cmd=showdetailview&indexed=google permission pending</center>
 <br>

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 While the finite number effect is the most recognized source of stochasticity in gene expression, translational bursting is the most prevalent.
 <br>
-[[Image:Noise_strength.png| 300 px]]
+<center>Figure 2 <br>[[Image:Noise_strength.png| 300 px]]
 <br>
 This image depicts The dependencies of [[ Noise as a Variable | noise and noise strength]] on the average protein abundance when transcription rate and translational efficiency are increased. Green represents the varying translational effciency and pink represents the varying transcriptional rate. When comparing the slopes of the lines in figure B, translational effciency has a much greater effect on noise strength.
 <br><br><br>
 <center>[[Promoter Kinetics |Next Section in Origins and Characterization]] | [[Origins and Characterization of Stochasticity | Back to Origins and Characterization Home]]</center>

@@ Line 3: / Line 3: @@
 <br>
 <center>Figure 1 <br>[[Image:Translationalbursting.png | 250 px]]<br> Image obtained from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400249 permission pending <br>
-Figure 1 visually the varying levels of noise in response to varying levels of mRNA and translational efficieny. Due to the stochastic nature of translation, larger concentrations of mRNA result in less stochasticity as a result of translational machinery.</center>
+Figure 1 visually depicts the varying levels of noise in response to varying levels of mRNA and translational efficieny. Due to the stochastic nature of translation, larger concentrations of mRNA result in less stochasticity as a result of translational machinery.</center>