Difference between revisions of "Davidson Missouri W"
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|style="color: red; background-color: black;" align="center"| '''Davidson''' <br> [[Oyinade Adefuye]] <br> [[Will DeLoache]] <br> [[Jim Dickinson]] <br> [[Andrew Martens]] <br> [[ Amber Shoecraft]] <br> [[Mike Waters]] | |style="color: red; background-color: black;" align="center"| '''Davidson''' <br> [[Oyinade Adefuye]] <br> [[Will DeLoache]] <br> [[Jim Dickinson]] <br> [[Andrew Martens]] <br> [[ Amber Shoecraft]] <br> [[Mike Waters]] | ||
| − | |style="color: red; background-color: black;" align="center"| | + | |style="color: red; background-color: black;" align="center"| [[A. Malcolm Campbell ]] <br> [[Karmella Haynes]] <br> [[Laurie Heyer]] |
|- | |- | ||
| − | |style="color: yellow; background-color: black;" align="center"|Jordan Baumgardner <br> Tom Crowley <br> Lane H. Heard <br> Nickolaus Morton <br> Michelle Ritter <br> Jessica Treece <br> Matthew Unzicker <br> Amanda Valencia | + | |style="color: yellow; background-color: black;" align="center"|'''Missouri Western'''<br>Jordan Baumgardner <br> Tom Crowley <br> Lane H. Heard <br> Nickolaus Morton <br> Michelle Ritter <br> Jessica Treece <br> Matthew Unzicker <br> Amanda Valencia |
|style="color: yellow; background-color: black;" align="center"|Todd Eckdahl <br> Jeff Poet | |style="color: yellow; background-color: black;" align="center"|Todd Eckdahl <br> Jeff Poet | ||
|} | |} | ||
Revision as of 21:09, 28 June 2007
| The Team | The Faculty | |
|---|---|---|
| Davidson Oyinade Adefuye Will DeLoache Jim Dickinson Andrew Martens Amber Shoecraft Mike Waters |
A. Malcolm Campbell Karmella Haynes Laurie Heyer | |
| Missouri Western Jordan Baumgardner Tom Crowley Lane H. Heard Nickolaus Morton Michelle Ritter Jessica Treece Matthew Unzicker Amanda Valencia |
Todd Eckdahl Jeff Poet | |
| In Depth | Overview | ||
|---|---|---|---|
| Probability and Statistics Gene splitting Controlling Expression Hix Insertion Possible Constructs History |
Hamiltonian Path Problem As a part of iGEM2006, a combined team from Davidson College and Missouri Western State University reconstituted a hin/hix DNA recombination mechanism which exists in nature in Salmonella as standard biobricks for use in E. coli. The purpose of the 2006 combined team was to provide a proof of concept for a bacterial computer in using this mechanism to solve a variation of The Pancake Problem from Computer Science. This task utilized both biology and mathematics students and faculty from the two institutions.
For 2007, we continue our collaboration and our efforts to manipulate E. coli into mathematics problem solvers as we refine our efforts with the hin/hix mechanism to explore another mathematics problem, the Hamiltonian Path Problem. This problem was the subject of a groundbreaking paper by Adelman in 1994 (citation below) where a unique Hamiltonian path was found in vitro for a particular directed graph on seven nodes. We propose to make progress toward solving the particular problem in vivo.
| ||
| Project | Short Description | |
|---|---|---|
| Burnt Pancake Problem | Flipping DNA "Pancakes" with hix "spatualas" until the pancakes are in the correct order and orientation | |
| Traveling Salesman Problem and Anti-terminators | Solving the Hamiltonian Path problem AND minimizing distance traveled | |
| Spliting Genes Web Tool | A Davidson iGEM 2007-designed primer sequencer for gene splitting | |
| Backwards promotion and read-though transcription | Davidson's investigation into control of "leaky" gene expression | |
Resources / Citations
Missouri Western's Wet Lab Protocols
- DMW Part Numbers for 2007 are BBa_I715000 to BBa_I715999.
- How to Name a New Part
- Entering the Part to the Registry
- How to Annotate a Part
Cool site for Breakfast [1]
Karen Acker's paper describing GFP and TetA(c) with Hix insertions [2]
Bruce Henschen's paper describing one-time flippable Hix sites [3]
Intro to Hamiltonian Path Problem and DNA [4]
Adleman, LM. Molecular Computation of Solutions To Combinatorial Problems. Science. 11 November 1994. Vol. 266. no. 5187, pp. 1021 - 1024
Ptashne, Mark. A Genetic Switch: Phage Lambda Revisited, Third Edition. New York. Cold Spring Harbor Laboratory Press: 2004.
Sambrook and Russell. 2001. Molecular Cloning A Laboratory Manual. Cold Spring Harbor Laboratry Press. Cold Spring Harbor, New York pg. 1.145. 2007 June.
