Difference between revisions of "CellularMemory:Hysteresis in Mammalian Cells"

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=<center>Synthetic Hysteresis in Mammalian Cells</center>=
 
=<center>Synthetic Hysteresis in Mammalian Cells</center>=
 
==Overview==
 
==Overview==
[[Image:Hysteresis.png|thumb|300px|left|'''A graphical depiction of [http://en.wikipedia.org/wiki/Hysteresis hysteresis].''' Arrows indicate the direction of movement from one state to another. For a system that exists in the low output state initially (red line), a relatively high level of input is required to induce a change to a high system output. For a system that exists in the high state initially (blue line), a relatively low level of input is required to induce a change to a low system output. In other words, more extreme amounts of input are required to move out of a state than are required to move into a state (meaning that the system resists a change of state).]]  
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[[Image:Hysteresis.png|thumb|300px|right|'''A graphical depiction of [http://en.wikipedia.org/wiki/Hysteresis hysteresis].''' Arrows indicate the direction of movement from one state to another. For a system that exists in the low output state initially (red line), a relatively high level of input is required to induce a change to a high system output. For a system that exists in the high state initially (blue line), a relatively low level of input is required to induce a change to a low system output. In other words, more extreme amounts of input are required to move out of a state than are required to move into a state (meaning that the system resists a change of state).]]  
 
[[Image:Linebreak.png]]
 
[[Image:Linebreak.png]]
 
==Biological Design==
 
==Biological Design==
[[Image:Hysteresis design.png|thumb|300px|left|The biological design of hysteresis.]]
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[[Image:Hysteresis design.png|thumb|300px|right|The biological design of hysteresis.]]
 
[[Image:Linebreak.png]]
 
[[Image:Linebreak.png]]
 
==Mathematical Model==
 
==Mathematical Model==

Revision as of 17:45, 20 November 2007

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Synthetic Hysteresis in Mammalian Cells

Overview

A graphical depiction of hysteresis. Arrows indicate the direction of movement from one state to another. For a system that exists in the low output state initially (red line), a relatively high level of input is required to induce a change to a high system output. For a system that exists in the high state initially (blue line), a relatively low level of input is required to induce a change to a low system output. In other words, more extreme amounts of input are required to move out of a state than are required to move into a state (meaning that the system resists a change of state).

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Biological Design

The biological design of hysteresis.

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Mathematical Model

Results

Kramer, B.P. and Fussenegger, M. 2005. Hysteresis in a synthetic mammalian gene network. Proc. Natl. Acad. Sci. 102: 9517-9522.


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