Difference between revisions of "Eric"
From GcatWiki
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MZ1/MZ2<br> | MZ1/MZ2<br> | ||
-supernumerary<br> | -supernumerary<br> | ||
| − | RPKM-reads per kilobase million | + | RPKM-reads per kilobase million -gives you a normal for comparison |
| + | |||
| + | LADs are overtranscribed in down syndrome when they should have low expression | ||
| + | |||
| + | Think replication time and transcription levels are correlated, genes transcribed earlier are expressed lower and later transcribed are more expressed | ||
| + | |||
| + | Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure | ||
Revision as of 15:52, 19 January 2017
January 19th Lab Methods in Genomics
Ts65DnDown Syndrome mouse model
T1DS/T2N -twin 1 down syndrome/twin 2 normal
MZ1/MZ2
-supernumerary
RPKM-reads per kilobase million -gives you a normal for comparison
LADs are overtranscribed in down syndrome when they should have low expression
Think replication time and transcription levels are correlated, genes transcribed earlier are expressed lower and later transcribed are more expressed
Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure
