Difference between revisions of "Eric"

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Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure
 
Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure
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[http://bio.davidson.edu/Courses/Bio343/2017/4_16break_point.pdf Molecular characterization of Ts65Dn] <br>
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Ts65Dn is the mouse model for trisomy 21 in humans

Revision as of 14:48, 31 January 2017

January 19th Lab Methods in Genomics

Tester.png


Ts65DnDown Syndrome mouse model
T1DS/T2N -twin 1 down syndrome/twin 2 normal
MZ1/MZ2
-supernumerary
RPKM-reads per kilobase million -gives you a normal for comparison

LADs are overtranscribed in down syndrome when they should have low expression

Think replication time and transcription levels are correlated, genes transcribed earlier are expressed lower and later transcribed are more expressed

Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure


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Molecular characterization of Ts65Dn


Ts65Dn is the mouse model for trisomy 21 in humans