Eric

January 19th Lab Methods in Genomics

Ts65DnDown Syndrome mouse model
T1DS/T2N -twin 1 down syndrome/twin 2 normal
MZ1/MZ2
-supernumerary
RPKM-reads per kilobase million -gives you a normal for comparison

LADs are overtranscribed in down syndrome when they should have low expression

Think replication time and transcription levels are correlated, genes transcribed earlier are expressed lower and later transcribed are more expressed

Not just the overexpression of chromosome 21. It is the consequence of these products causing the LADs to be expressed higher. Effects of changing chromatin structure

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Molecular characterization of Ts65Dn

Ts65Dn is the mouse model for trisomy 21 in humans