Histone Deacetylase (Katie Richeson)
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Histone Deacetylase (644029844)
What is a Histone Deacetylase?
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by removing or adding acetyl groups to lysine located near the amino termini of histone proteins. When HAT adds an acetyl group to a histone transcriptional activity changes, whereas deactylation leads to gene silencing. "HDACs are also involved in the reversible acetylation of non-histone proteins" [Vinci-Biochem].
Histone Acetylation in eukarya is a form of epigenetic regulation, where the density of chromatin is affected leading to changes in transcriptional rates.
