Difference between revisions of "3) Heat shock genes"

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         What is the role of [http://www.medterms.com/script/main/art.asp?articlekey=33421 peptidase] (enzyme that breaks down peptide bonds) in the heat shock gene mechanism?  
 
         What is the role of [http://www.medterms.com/script/main/art.asp?articlekey=33421 peptidase] (enzyme that breaks down peptide bonds) in the heat shock gene mechanism?  
 
          
 
          

Revision as of 21:09, 9 September 2009

Heat Shock Genes

Our halophile's (Halomicrobium mukohataei) genome has 2 heat shock genes: Heat shock protein (644030037) and Heat shock protein (644032460).

Confirmed Annotation for Both Genes:

   Heat Shock Gene 644030037 (247059..247886(-) (828bp)) 
    
        ATG confirmed start codon with a Met in the amino acid sequence.
        
        Blastp results (using the translated amino acid sequence seen below): 
      
        Blastp.jpg
        
        What is the role of peptidase (enzyme that breaks down peptide bonds) in the heat shock gene mechanism? 
       
        GC content: 0.66 consistent with the GC content of 0.65 in our genome           


    Heat Shock gene 644032460 (2587941..2588783(+) (843bp))


Possible Other Questions of Interest:

1). Are these two gene's paralogs, orthologs or alien genes?

2). Do other halophiles have heat shock genes?

3). Do eukarya and prokarya have heat shock genes? If so how do the number and sequence of heat shock genes compare to that of other species and domains.

4). Our halophile has five cold shock genes. Do these genes operate under the same mechanism as heat shock genes? Why are there more cold shock than heat shock genes?

5). By what mechanism do heat shock genes in archaea up-regulate a specific series of genes that are more suitable for hotter environments?

6). By what mechanism do heat shock genes in bacteria and eukarya change the transcription of certain genes? Does a difference in mechanisms account for the some genes that exist in our species but not in the other domains?

7). Do halophiles that live in extreme heat have heat shock genes?


Articles that may be of future use: