Difference between revisions of "8) Start codon issues"
Karicheson (talk | contribs) (→Alternative Start Codon Issues) |
Karicheson (talk | contribs) (→Alternative Start Codon Issues) |
||
| Line 3: | Line 3: | ||
Possible start codons AUG (most common in archaea), GUG and UUG [1]. | Possible start codons AUG (most common in archaea), GUG and UUG [1]. | ||
| − | Olivia came across a very interesting conundrum because she checked and tried to verify a lot of the computer's work | + | |
| + | Olivia came across a very interesting conundrum because she checked and tried to verify a lot of the computer's work: | ||
When the start codon is not AUG, is the first amino acid in the protein's primary sequence a Met or the correct amino acid for that codon triplet? | When the start codon is not AUG, is the first amino acid in the protein's primary sequence a Met or the correct amino acid for that codon triplet? | ||
I think it would be an interesting side study but it may require wet lab work to decipher whether or not the first amino acid is really Met when an alternative start codon is used. It may also be interesting to look for a trend in the genes that begin with an alternative start codon. | I think it would be an interesting side study but it may require wet lab work to decipher whether or not the first amino acid is really Met when an alternative start codon is used. It may also be interesting to look for a trend in the genes that begin with an alternative start codon. | ||
| + | |||
There is not much published research I could find on this issue but the articles/links below are summarized: | There is not much published research I could find on this issue but the articles/links below are summarized: | ||
Revision as of 21:51, 9 September 2009
Alternative Start Codon Issues
Possible start codons AUG (most common in archaea), GUG and UUG [1].
Olivia came across a very interesting conundrum because she checked and tried to verify a lot of the computer's work:
When the start codon is not AUG, is the first amino acid in the protein's primary sequence a Met or the correct amino acid for that codon triplet?
I think it would be an interesting side study but it may require wet lab work to decipher whether or not the first amino acid is really Met when an alternative start codon is used. It may also be interesting to look for a trend in the genes that begin with an alternative start codon.
There is not much published research I could find on this issue but the articles/links below are summarized:
Good Articles to Reference:
1. Transcription and translation in Archaea: a mosaic of eukaryal and bacterial features.
