Directed Evolution and Synthetic Biology - Hunter Stone
From GcatWiki
Project Proposal
My project will focus on attempts to utilize random mutations for optimization of synthetic pathways. Mathematical modeling of synthetic pathways is a powerful, proven tool to maximize product output. However, authors have recently shown that recombinant methods can be used to discover previously unknown elements of cell metabolism that will increase product yield even further. These methods of directed evolution have also been used to create powerful tools like promoters of specific expression levels, further increasing the relevance and importance of these methods to synthetic biology.
