Helix-Slipping

Helix-slipping uses a sequence that forms an imperfectly paired double-stranded stem that is flexible in its nucleotide base-pairing through a "slip-structure" mechanism. It does not allow for rational design and results in disruption or restoration of the hammerhead ribozyme in response to changes in the aptamer.

http://www.pnas.org/content/vol104/issue36/images/large/zpq0340773700003.jpeg

Links

Ribozyme Switch