How does it compare to HTSeq?

A Python library to facilitate the rapid development of such scripts. HTSeq offers...classes to represent data, such as genomic coordinates, sequences, sequencing reads, alignments, gene model information and variant calls, and provides data structures that allow for querying via genomic coordinates. The researchers also present htseq-count, a tool developed with HTSeq that preprocesses RNA-Seq data for differential expression analysis by counting the overlap of reads with genes (Source: http://www.rna-seqblog.com/htseq-a-python-framework-to-work-with-high-throughput-sequencing-data/)