JP Apr 07 16
Last day to figure out our story before oral presentation.
Found a cool gene. - Possible OFF response being queued up at start of feeding.
Codes for 4EBP1 protein which binds to eIF4E and inhibits it
eIF4E is an initiation of translation limiting factor
4EBP1 are negative regulators of cell growth by acting on the translational process of the cell
Can be unbound by insulin signaling -> cell growth
-phosphorylation = no interaction = cell growth
Insulin phosphorylates => cell growth
Insulin is raised during feeding. Falls after feeding.
--maybe the signal begins with the feeding process, and is preparing for an “off” signal (lowered insulin -> binding -> stop growth)