Manipulation of Stochasticity

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In Depth How Stochasticity Influences Synthetic Constructs

Noise in Synthetic Cascades

Noise in Feedback Loops

The construction of gene networks proves to be a noisy process; this makes obtaining a deterministic result difficult. Many labs have tried to characterize sources of expression noise that occur when linking genes together in a network. More specifically, what effect does a noisy vs. tightly controlled input have on output noise? Discovering the effects of noise propagation in genetic cascades has major implications in the field of synthetic biology. From an engineering standpoint, the degree of control over a synthetic system can mean the difference between a synthetic construct's success or failure to achieve its purpose (e.g. metabolic cascade, product formation pathway, cell differentiation pathway).

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