NHE Feb 4 Notes

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Nick Elder

Group 2 intestines

Questions to think about:

1. What are we trying to get and how will we get there?

  • What is the gene that triggers/begins the cascade of physiological changes in the small intestine?
  • Would be ideal if we could find a specific process that the differentially regulated genes control
  • Is the responsible gene only turned on or off for a small time range (quick switch) or does it stay on or off for a long period of time?

2. What do we need to do with each of the 12 data sets to be able to evaluate them later?

  • Look for housekeeping genes or tissue specific genes
  • If possible, confirm that we have the mucosa vs serosa
  • instead of looking at differential expression first, could search by function as determined by GO