Noise in Feedback Loops

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Some gene networks engage in the production of autoregulatory proteins. Collins details that an experiment run by Beckskei and Serrano characterized the effect of a negative feedback loop on noise in genetic autoregulatory networks. Becskei and Serrano generated a regulatory network and tested the noise strength in the absence of its negative feedback loop. The comparison between the two states revealed that negative-autoregulation reduces noise in an autoregulatory system. Collins also detailed that the usual outcome of positive-feedback regulation is bistability because it gives rise to cellular states of high and low expression levels (Collins et. al., 2005).

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