https://gcat.davidson.edu/GcatWiki/api.php?action=feedcontributions&feedformat=atom&user=Bewhitfield 2026-05-17T04:01:59Z User contributions MediaWiki 1.28.2 https://gcat.davidson.edu/GcatWiki/index.php?title=Paper_Notes&diff=18760 2017-01-24T14:40:41Z

<p>Bewhitfield: </p> <hr /> <div>[[Down Syndrome Transcriptome GEDDs]]<br /> <br /> [[DNA Methylation Parent of Origin]]</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Paper_Notes&diff=18759 2017-01-24T14:40:35Z

<p>Bewhitfield: </p> <hr /> <div>[[Down Syndrome Transcriptome GEDDs]]<br /> [[DNA Methylation Parent of Origin]]</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Down_Syndrome_Transcriptome_GEDDs&diff=18739 2017-01-19T15:52:07Z

<p>Bewhitfield: Created page with &quot;'''Terms''' ''Lamina associated domains(LADs)'': Areas of the chromosome which interact with the nuclear lamina. Are highly conserved across species and are often repressed....&quot;</p> <hr /> <div>'''Terms'''<br /> <br /> ''Lamina associated domains(LADs)'': Areas of the chromosome which interact with the nuclear lamina. Are highly conserved across species and are often repressed.<br /> <br /> ''H3K4me3'': Histone 3, Lysine 4, trimethylated. The fourth amino acid on the third histone is a trimethylated lysine.<br /> <br /> ''Supernumerary'': Present in excess<br /> <br /> ''RPKM'': Reads per kilobase per million per million.<br /> <br /> '''Mouse Strains'''<br /> <br /> ''Ts65Dn'': Mouse model for down syndrome.<br /> <br /> '''Figures'''<br /> <br /> ''Figure 1'': FC is correlated to conserved areas of the chromosome.<br /> <br /> ''Figure 2'': More highly expressed genes are more likely to be downregulated in T1DS and vice versa.<br /> <br /> ''Figure 3'': GEDDs are retained even in iPSC.<br /> <br /> ''Figure 4'': Loss of repression is consistent in syntenic regions across species. B conveys the DS mouse matches DS human, but not non-DS human.<br /> <br /> ''Figure 5&quot;: iLAD genes are not different between the T1DS and T2N, but LADs are different.<br /> <br /> ''Figure 6'': There is a correlation between replication time and FC, and between H3K4me3 modification and FC.<br /> <br /> '''Take away'''<br /> <br /> Dosage hypothesis is not entirely true. Instead, differential regulation of epigenetic factors, by triplicated genes (HLCS maybe?), is a large driving factor.</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Paper_Notes&diff=18736 2017-01-19T14:59:58Z

<p>Bewhitfield: Created page with &quot;Down Syndrome Transcriptome GEDDs&quot;</p> <hr /> <div>[[Down Syndrome Transcriptome GEDDs]]</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Ben&diff=18735 2017-01-19T14:59:08Z

<p>Bewhitfield: </p> <hr /> <div>Hello world!<br /> <br /> &lt;center&gt;<br /> [[File:terribletowel.png|300px]]<br /> &lt;/center&gt;<br /> <br /> [[Paper Notes]]</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Ben&diff=18729 2017-01-19T14:56:10Z

<p>Bewhitfield: </p> <hr /> <div>Hello world!<br /> <br /> &lt;center&gt;<br /> [[File:terribletowel.png|300px]]<br /> &lt;/center&gt;</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=File:Terribletowel.png&diff=18715 2017-01-19T14:53:08Z

<p>Bewhitfield: </p> <hr /> <div></div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Ben&diff=18711 2017-01-19T14:52:34Z

<p>Bewhitfield: </p> <hr /> <div>Hello world!<br /> <br /> [[File:terribletowel.png|300px]]</div>

Bewhitfield https://gcat.davidson.edu/GcatWiki/index.php?title=Ben&diff=18699 2017-01-19T14:46:51Z

<p>Bewhitfield: Created page with &quot;Hello world!&quot;</p> <hr /> <div>Hello world!</div>

Bewhitfield