DM Notes 3.31.16 - Revision history

Dymaghini at 18:56, 31 March 2016

2016-03-31T18:56:32Z

2016-03-31T18:55:13Z

2016-03-31T18:53:24Z

2016-03-31T18:44:37Z

2016-03-31T17:56:46Z

2016-03-31T16:59:08Z

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 *Merlin protein: tumor suppressor, found at adherens junctions, associated with contact-mediated growth inhibition.
 *FRMD6: human orthologue of Expanded in drosophila. FRMd6 causes increase in phosphorylation of core Hippo signaling pathway LATS1 and YAP. Activates kinase cassette.
-*FRMD1
+*FRMD1 parallel of FRMD1
 MAPK pathway: cell proliferation, differentiation, development, transformation, apoptosis.

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 *NF2: probable regulator of Hippo pathway, production of merlin protein. Merlin controls cell shape, cell movement, communication between cells. Merlin functions as tumor suppressor (prevents cells from growing/dividing too fast).
 *Merlin protein: tumor suppressor, found at adherens junctions, associated with contact-mediated growth inhibition.
-*FRMD6
+*FRMD6: human orthologue of Expanded in drosophila. FRMd6 causes increase in phosphorylation of core Hippo signaling pathway LATS1 and YAP. Activates kinase cassette.
 *FRMD1

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 *STK3: down regulated across the board. Encodes serine/threonin protein kinase, acts as a growth suppressor. "Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis." Involved in the MAPK signaling pathway-- communicates signal from receptor on surface of cell to DNA in nucleus of cell. Defect in MAPK can lead to uncontrolled cell growth. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
 *WWC1: regulates Hippo pathway, not much further info
-*NF2: probable regulator of Hippo pathway,
+*NF2: probable regulator of Hippo pathway, production of merlin protein. Merlin controls cell shape, cell movement, communication between cells. Merlin functions as tumor suppressor (prevents cells from growing/dividing too fast).
 *FRMD6
 *FRMD1

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 Genes that interact with TEAD3 (hippo):
-*STUB1: protein homodimerization, ligase activity. Proteasomal degradation.
+*STUB1: protein homodimerization, ligase activity. Proteasomal degradation. Misfiled protein binding.
-*VGLL4:
+*VGLL4:Transcription cofactor vestigial-like protein 4. Competes with YAP for binding TEADs. Acts as a tumor/growth suppressor, inhibits activity of YAP-TEAD transcriptional complex.
-*GTPBP8
+*GTPBP8: GTP binding, ferrous iron transmembrane transporter activity. GTP binding could be significant, it's an energy source in metabolic reactions (specifically for protein synthesis, gluconeogenesis).
 Back to home [[Dylan Maghini]]

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+Genes that interact with TEAD3 (hippo):
+*STUB1: protein homodimerization, ligase activity. Proteasomal degradation.
 Back to home [[Dylan Maghini]]