Difference between revisions of "Weekly Discussions"
From GcatWiki
(→19 January 2010') |
|||
Line 15: | Line 15: | ||
Meeting with Dr. Campbell | Meeting with Dr. Campbell | ||
− | * went through papers | + | * went through papers - paper simulating how noise can continue an oscillatory system |
* positive feedback loops are important | * positive feedback loops are important | ||
* Minesweeper --> maybe Battleship | * Minesweeper --> maybe Battleship | ||
Line 21: | Line 21: | ||
* maybe some cell differentiation using +/- feedback | * maybe some cell differentiation using +/- feedback | ||
* maybe some antenna-ish like sampling - a Biosensor - cell has lots of sensors, randomly sample for something, if detect something with one of the sensors then report...do something else while other cells can keep sensing | * maybe some antenna-ish like sampling - a Biosensor - cell has lots of sensors, randomly sample for something, if detect something with one of the sensors then report...do something else while other cells can keep sensing | ||
+ | |||
+ | = 25 January 2010 = | ||
+ | |||
+ | I still like the oscillatory idea - noise driving oscillation --> What is oscillation good for? | ||
+ | Combining oscillation and quorum sensing - synchronize system | ||
+ | |||
+ | Biosensors = about the promoter - want sensor up/down (on/off, like an antenna) from cell to cell to sense environment --> can maybe start positive feedback loop to amplify report / signal |
Revision as of 19:24, 14 February 2010
19 January 2010
Why make something noisy?
- The benefit of sampling
- or maybe trying every ombination along a spectrum
- a maze
- Minesweeper? - except a wrong turn can't be completely detrimental to the whole system .... maybe though - aging / death discussion
Positive feedback loops --> bistable, bimodal phenotype
- ex. S. cerevisiae with galactose (Acar paper) - have 2 positive, 1 negative - negative allows switching between states
- perhaps the two states can be complementary to each other
- random on/off transition
- barcodes? decoding, decrypting - combination lock-ish - bacteria as a random number generator - stops when it fits the "slot"
Meeting with Dr. Campbell
- went through papers - paper simulating how noise can continue an oscillatory system
- positive feedback loops are important
- Minesweeper --> maybe Battleship
- the aging papers Dr. C sent - thinking can somehow randomly switch something on, if beneficial to survival @ that time, will select for those and kill the others
- maybe some cell differentiation using +/- feedback
- maybe some antenna-ish like sampling - a Biosensor - cell has lots of sensors, randomly sample for something, if detect something with one of the sensors then report...do something else while other cells can keep sensing
25 January 2010
I still like the oscillatory idea - noise driving oscillation --> What is oscillation good for? Combining oscillation and quorum sensing - synchronize system
Biosensors = about the promoter - want sensor up/down (on/off, like an antenna) from cell to cell to sense environment --> can maybe start positive feedback loop to amplify report / signal