Vocabulary
5mCpG
Androgenic hydatidiform mole
Bisulfite conversion
Capillary electrophoresis
CpG Islands/Sites
DMR:differentially methylated region; stretches of DNA in an organism’s genome that have different DNA methylation patterns compared to other samples
gDMR
hESC
HhaI: a methylation sensitive restriction enzyme that won’t cleave DNA in methylated region.
ICR
MSRE-PCR
MT21: nuclear family trio with Down syndrome of maternal origin
N21:"normal" nuclear family trio without Down syndrome
NCBI GEO Nondisjunction
Oogenesis: The development of a mature egg cell (ovum) from the primary oocyte.
Proband: A person that is used as the starting point for a family in a genetic study. A term used especially in medicine or psychiatry.
PT21: nuclear family trio with Down syndrome of paternal origin
rs#
SNP: single nucleotide polymorphisms; difference in a single nucleotide at a specific position; the most common type of genetic variation among people
SNuPE SRA
STR: Short tandem repeats. A region of the DNA two-thirteen bases long that is repeated up to hundreds of times. These regions can be used to trace lineage
TSS
WRB: Tryptophan Rich Basic Protein coding gene. This gene codes for a nuclear protein of unknown function. Known as a critical region for Down Syndrome because it is linked to congenital heart disease and heart disease.