CTP Synthase (Sarah Pyfrom)

CTP synthase

ID Number: 644032266

Biological process: pyrimidine biosynthesis.

Molecular function: converts UTP to CTP.

Cellular component: cytoplasm?

Cytidine 5'-triphosphate (CTP) synthase uses either ammonia or L-glutamine as the source of nitrogen in order to transform UTP into CTP. MacDonnell JE, Lunn FA, Bearne SL.

Figure 1. Conversion of UTP to CTP by CTP synthase using the NH2 group from Glutamine and ATP as the activator. CTP synthase is activated by either GTP or ATP, converting them into ADP or GDP respectively. A (adenine) and G (guanine) are both purines. By deconstructing a purine in order to form a pyrimidine, CTP synthase can affect the balance of purines to pyrimidines.

Glutamine pathway:

Even though ATP is required for synthesis of CTP by CTP synthase, GTP is also necessary as an allosteric moderator when glutamine is used as the substrate.MacDonnell JE, Lunn FA, Bearne SL.

Functions of CTP synthase:

It has been shown that ratios of UTP:CTP can control or regulate other enzymes such as ATCase. GA O'Donovan, S Herlick, DE Beck, PK Dutta

BLASTp

BLASTp hits confirm that high identity is found between CTP synthases in many other species and Halomicrobium mukohataei.