Difference between revisions of "DM Notes 3.31.16"
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Genes that interact with TEAD3 (hippo): | Genes that interact with TEAD3 (hippo): | ||
| − | *STUB1: protein homodimerization, ligase activity. Proteasomal degradation. | + | *STUB1: protein homodimerization, ligase activity. Proteasomal degradation. Misfiled protein binding. |
| − | *VGLL4: | + | *VGLL4:Transcription cofactor vestigial-like protein 4. Competes with YAP for binding TEADs. Acts as a tumor/growth suppressor, inhibits activity of YAP-TEAD transcriptional complex. |
| − | *GTPBP8 | + | *GTPBP8: GTP binding, ferrous iron transmembrane transporter activity. GTP binding could be significant, it's an energy source in metabolic reactions (specifically for protein synthesis, gluconeogenesis). |
| + | |||
| + | Early genes in the pathway: | ||
| + | *STK3: down regulated across the board. Encodes serine/threonin protein kinase, acts as a growth suppressor. "Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis." Involved in the MAPK signaling pathway-- communicates signal from receptor on surface of cell to DNA in nucleus of cell. Defect in MAPK can lead to uncontrolled cell growth. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation | ||
| + | *WWC1: regulates Hippo pathway, not much further info | ||
| + | *NF2: probable regulator of Hippo pathway, | ||
| + | *FRMD6 | ||
| + | *FRMD1 | ||
| + | |||
| + | MAPK pathway: cell proliferation, differentiation, development, transformation, apoptosis. | ||
Back to home [[Dylan Maghini]] | Back to home [[Dylan Maghini]] | ||
Revision as of 18:44, 31 March 2016
Genes that interact with TEAD3 (hippo):
- STUB1: protein homodimerization, ligase activity. Proteasomal degradation. Misfiled protein binding.
- VGLL4:Transcription cofactor vestigial-like protein 4. Competes with YAP for binding TEADs. Acts as a tumor/growth suppressor, inhibits activity of YAP-TEAD transcriptional complex.
- GTPBP8: GTP binding, ferrous iron transmembrane transporter activity. GTP binding could be significant, it's an energy source in metabolic reactions (specifically for protein synthesis, gluconeogenesis).
Early genes in the pathway:
- STK3: down regulated across the board. Encodes serine/threonin protein kinase, acts as a growth suppressor. "Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis." Involved in the MAPK signaling pathway-- communicates signal from receptor on surface of cell to DNA in nucleus of cell. Defect in MAPK can lead to uncontrolled cell growth. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
- WWC1: regulates Hippo pathway, not much further info
- NF2: probable regulator of Hippo pathway,
- FRMD6
- FRMD1
MAPK pathway: cell proliferation, differentiation, development, transformation, apoptosis.
Back to home Dylan Maghini
