Difference between revisions of "Noise in Feedback Loops"
From GcatWiki
| Line 1: | Line 1: | ||
Some gene networks engage in the production of autoregulatory proteins. Collins details that an experiment run by Beckskei and Serrano characterized the effect of a negative feedback loop on noise in genetic autoregulatory networks. Becskei and Serrano generated a regulatory network and tested the noise strength in the absence of its negative feeedback loop. The comparision between the two states revealed that negative-autoregulation reduces noise in an autoregulatory system. | Some gene networks engage in the production of autoregulatory proteins. Collins details that an experiment run by Beckskei and Serrano characterized the effect of a negative feedback loop on noise in genetic autoregulatory networks. Becskei and Serrano generated a regulatory network and tested the noise strength in the absence of its negative feeedback loop. The comparision between the two states revealed that negative-autoregulation reduces noise in an autoregulatory system. | ||
| − | Collins also detailed that the usual outcome of positive-feedback regulation is bistability becuase it gives rise to cellular states of high and low expression levels (Collins, 2005). | + | Collins also detailed that the usual outcome of positive-feedback regulation is bistability becuase it gives rise to cellular states of high and low expression levels (Collins et. al., 2005). |
<br><br><br> | <br><br><br> | ||
<center>[[Manipulation of Stochasticity | Return to Manipulation of Stochasticity]] </center> | <center>[[Manipulation of Stochasticity | Return to Manipulation of Stochasticity]] </center> | ||
Revision as of 17:19, 6 December 2007
Some gene networks engage in the production of autoregulatory proteins. Collins details that an experiment run by Beckskei and Serrano characterized the effect of a negative feedback loop on noise in genetic autoregulatory networks. Becskei and Serrano generated a regulatory network and tested the noise strength in the absence of its negative feeedback loop. The comparision between the two states revealed that negative-autoregulation reduces noise in an autoregulatory system.
Collins also detailed that the usual outcome of positive-feedback regulation is bistability becuase it gives rise to cellular states of high and low expression levels (Collins et. al., 2005).
