Noise in Feedback Loops
From GcatWiki
Some gene networks engage in the production of autoregulatory proteins. Collins details that an experiment run by Beckskei and Serrano characterized the effect of a negative feedback loop on noise in genetic autoregulatory networks. Becskei and Serrano generated a regulatory network and tested the noise strength in the absence of its negative feeedback loop. The comparision between the two states revealed that negative-autoregulation reduces noise in an autoregulatory system.
Collins also detailed that the usual outcome of positive-feedback regulation is bistability becuase it gives rise to cellular states of high and low expression levels (Collins et. al., 2005).
