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Finite Number Effect
Translational Bursting
Promoter Kinetics
Stochasticity in a Eukaryotic Background
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Manifestations of stochasticity in cellular protein production are observable in processes both intrinsic and extrinsic to the gene in question. Intrinsic stochasiticy is characterized as that which is inherent in the processes of transcription and translation (ex. Gillsepe Model); extrinsic stochasticity is characterized as that which arises from other sources (ex. Presence of RNAP/ribosomes/mRNA degredation machinery, stage in cell cycle, or plasmid copy number.) While in theory stochasticity of protein production comes from many sources, many labs have sought to distinguish dominant causes from neglible ones. Different parameters and independent variables aside, there are underlying motifs in the characterization of stochasticiiy between studies.
A Prokaryotic vs. a Eukaryotic background is an important distinction to make when characterizing stochasticity. Differences in transcriptional and translational processes lead to differences in dominant manifestations of non-genetic identity. In prokaryotes however Ozbudak et. al. characterized a modular model of expression noise in prokaryotic Bacilus Subtillis.
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