How is it different from DESeq2?

DESeq2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302049/ (Some direct quotes at the moment)

A method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates. This enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.

Ideal for data sets with a small sample size due to compound comparisons within and between samples. Uses comparative means across the whole genome.

Data read as (Samples) vs. (Gene), or rather a matrix with reads mapped to gene in a specific sample

Mostly used for RNA seq, but also some other methods (HTS assays), such as chromatin immunoprecipitation sequencing, chromosome conformation capture, or counting observed taxa in metagenomic studies.

Improved version of DESeq (1).