January 26, 2016

Article Discussion

"Rapid Changes in Gene Expression Direct Rapid Shifts in Intestinal Form and Function in the Burmese Python after Feeding" (2015)

• Provides the names of specific genes involved in the postprandial response of Pythons.
• Lots of genes change expression levels within the first 6 hours post-feeding.
• Introduces the potential involvement of the WNT signaling pathway.
• The anterior third of the Small Intestine experiences the most differential gene expression.
• Cell death and growth are occurring.
• The NIH provided funding for this project because understanding the genes and mechanisms involved in the postprandial adaptations of Pythons could have the potential to enhance treatment of human diseases.

Questions to Consider:

• How different will the genes from our sample (30 minutes) be from the sample (6 hours) of the Andrew et al. (2015) study?
• Can we compare our number of reads to the Andre et al. (2015) study number of reads?
• Can we get the names of the genes?

Ashlyn's Main Page

References"

• Andrew, Audra L., et al. “Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding.” Physiol Genomics. 47 (2015): 147-157.

Andrew et al. (2015)