NHE Jan 19 Notes

[[1]]

[[2]]

Nick Elder

Group 2 intestines

Regulatory Peptides (2001)

• lots of hormones and peptides
• intestine changes before the meal reaches it
• we hypothesize that active eating activates hormone response; looking early on, hours after eating
• enzymes need to make the hormones and then we need the receptors
  • plasma membrane or cytoplasm
• some of the mammalian antibodies cross react - no the intended target
• used column chromatography to try to identify reptilian versions of synthetically produced human homologs

Adaptive Regulation (2007)

• Fig 1. ever letter is sig. dif. from other letters
• change in intestine mass is from hypertrophy - cells grow bigger, not replication
  • cell division increased, but so did apoptosis
• enterocytes increase volume
• transport proteins may already exist in intracellular membranes that are then released to the luminal membrane
• would not result in a peak in RNA transcription
• part of why the cells are fatter is because they cells are full of lipid droplets
  • endocytosis - not actively transported